Regardless of what climate you grew up in or live in, genetics play a large role in how your core temperature affects your daily response to hot or cold environments. A common mutation or genetic variant found in the skeletal muscle gene called ACTN3 (alpha-actinin-3) makes it easier for people to tolerate cold temperatures. The ACTN3 gene produces a protein of the same name. Research shows that if you have this gene mutation or alpha-actinin-3 deficiency, you can maintain a higher core temperature, conserve more energy and shiver less when exposed to cooler temperatures than those who have more ACTN3 genes. Learn more about the hot and cold genes.
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